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Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach

dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorOlvera-Alvarez, María Irmaes_ES
dc.creatorAlvarez-Herrera, Samanthaes_ES
dc.creatorMaldonado-García, Jose Luises_ES
dc.creatorLópez-Torrez, Adolfoes_ES
dc.creatorRamírez-Marroquín, Oscar Abelardoes_ES
dc.creatorGonzález-Ruiz, Octavioes_ES
dc.creatorNogueira-Fernández, José Manueles_ES
dc.creatorMendoza-Contreras, José Manueles_ES
dc.creatorSánchez-García, Héctor Omares_ES
dc.creatorJosé-Alfallo, José Antonioes_ES
dc.creatorValencia Baños, Atenodoroes_ES
dc.creatorTorres-Serrano, Ana Bertaes_ES
dc.creatorJiménez-Genchi, Janethes_ES
dc.creatorMendieta-Cabrera, Daneliaes_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorPavón, Lenines_ES
dc.date2022
dc.date.accessioned2024-12-09T17:50:41Z
dc.date.available2024-12-09T17:50:41Z
dc.date.issued2022
dc.identifierJC05NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8143
dc.identifier.urihttps://doi.org/10.3389/fpsyt.2022.859768
dc.descriptionAirline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help in the diagnosis of depression. The genes SLC6A4 and S100A10 encode serotonin transporter (SERT) and p11 protein, respectively. Their expression has been frequently associated with stress and depression. In this work, we quantified, by quantitative PCR, the expression of SERT and p11 in peripheral mononuclear cells of airline pilots compared to patients with depression and healthy volunteers. Moreover, by mass spectrometry, we quantified the serum serotonin levels in the same three groups. We found that SERT and p11 were overexpressed in the mononuclear cells of airline pilots and depressed patients compared to healthy volunteers. Although serum serotonin was not different between healthy volunteers and airline pilots, a decreasing trend was observed in the latter. As expected, serum serotonin in the patients was significantly lower. Alterations in SERT and p11 in airline pilots could be related to professional stress, a condition that could potentially affect their long-term mental health.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.relation13:859768
dc.rightsAcceso Cerradoes_ES
dc.titleScreening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approaches_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Psicoinmunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
dc.contributor.emailgilberto.perez.sanchez@imp.edu.mx (Gilberto Pérez-Sánchez); lkuriaki@imp.edu.mx (Lenin Pavón)
dc.relation.jnabreviadoFRONT PSYCHIATRY
dc.relation.journalFrontiers in Psychiatry
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1664-0640
dc.identifier.doi10.3389/fpsyt.2022.859768
dc.subject.kwStress
dc.subject.kwDepression
dc.subject.kwAirline pilots
dc.subject.kwSerotonin transporter
dc.subject.kwp11


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