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Looking for factors affecting functioning in euthymic patients with bipolar I disorder: the importance of cognitive complaints and BDNF's Val66Met polymorphism

dc.creatorYoldi-Negrete, Maríaes_ES
dc.creatorPalacios-Cruz, Linoes_ES
dc.creatorTirado-Durán, Elsaes_ES
dc.creatorJiménez-Rodríguez, Laura Ivonnees_ES
dc.creatorJiménez-Pavón, Joannaes_ES
dc.creatorHernández, Sandraes_ES
dc.creatorAguilar, Alejandroes_ES
dc.creatorMorales-Cedillo, Ingrid Pamelaes_ES
dc.creatorJiménez-Tirado, Marianaes_ES
dc.creatorFresán-Orellana, Anaes_ES
dc.creatorJuárez García, Franciscoes_ES
dc.creatorBecerra-Palars, Claudiaes_ES
dc.creatorCamarena-Medellin, Beatrizes_ES
dc.date2022
dc.date.accessioned2024-12-03T19:14:06Z
dc.date.available2024-12-03T19:14:06Z
dc.date.issued2022
dc.identifierOE04IC22es_ES
dc.identifier.issn0165-0327
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8127
dc.identifier.urihttps://doi.org/10.1016/j.jad.2022.01.006
dc.descriptionFunctioning in Bipolar Disorder (BD) is affected in a substantial proportion of patients. The impact of demographic, clinical, cognitive, and genetic factors on functioning has been shown individually; however, as a complex phenomenon, a global approach to identify the most relevant as well as possible interactions is needed. Methods: 102 patients with type I BD in euthymia were invited for evaluation of demographic, clinical, and cognitive characteristics as well as genotype for Val66Met polymorphism of BDNF gene to determine those associated with poor functioning according to the FAST scale cut-off score. Clinical evaluation included assessment of residual affective symptoms and anxiety. Cognitive evaluation included the COBRA scale, verbal memory, and executive functions testing. Results: Residual depressive symptoms, anxiety, cognitive complaints and being a Met carrier were more frequent in the poor functioning group and were entered in a logistic regression model. Being a Met carrier (OR=4.46, CI=1.19-16.67) and cognitive complaints (OR=1.29, CI= 1.13-1.46) were the most important predictors of poor functioning in type I BD. Limitations: Cross-sectional study, with select population limiting generalizability of findings. Conclusions: A better understanding of underlying factors affecting cognition, including the possible involvement of BDNF Val66Met polymorphism, its systematic evaluation and a continued search for targeted treatment, along with recognition and attention of residual affective and anxious symptoms might improve psychosocial outcomes such as functioning in this population.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevier/North-Holland Biomedical Presses_ES
dc.relation302:131-138
dc.rightsAcceso Cerradoes_ES
dc.titleLooking for factors affecting functioning in euthymic patients with bipolar I disorder: the importance of cognitive complaints and BDNF's Val66Met polymorphismes_ES
dc.typeArticuloes_ES
dc.contributor.affiliationLaboratorio de Epidemiología Clínica, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico
dc.contributor.emailcamare@imp.edu.mx (B. Camarena-Medellin)
dc.relation.jnabreviadoJ AFFECT DISORD
dc.relation.journalJournal of Affective Disorders
dc.identifier.placePaíses Bajos
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1573-2517
dc.identifier.doi10.1016/j.jad.2022.01.006
dc.subject.kwBipolar disorder
dc.subject.kwFunctionality
dc.subject.kwCognition
dc.subject.kwVal66Met
dc.subject.kwBDNF


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