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The M3‑TT Vaccine Decreases the Antinociceptive Efects of Morphine and Heroin in Mice

dc.creatorBarbosa‑Méndez, Susanaes_ES
dc.creatorMatus‑Ortega, Mauraes_ES
dc.creatorHernández Miramontes, Ricardoes_ES
dc.creatorSalazar‑Juárez, Albertoes_ES
dc.date2023
dc.date.accessioned2024-04-09T15:39:28Z
dc.date.available2024-04-09T15:39:28Z
dc.date.issued2023
dc.identifierOE03IC21es_ES
dc.identifier.issn1557-1874
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7939
dc.identifier.urihttps://doi.org/10.1007/s11469-021-00621-z
dc.descriptionOpioid use disorder is a public health problem worldwide. Currently, its efects are exacerbated by the absence of efective therapy. Active vaccination is likely to be a good therapeutic option. Opioid-drug vaccines consist of an opioid-based small molecule called hapten which is conjugated to a carrier protein to enhance immunogenicity. Some studies have suggested that an appropriate position of attachment of the hapten to the carrier protein enhances the efcacy of an opioid-based vaccine. Conjugation of a carrier protein (toxoid tetanus (TT)) to position 3′ of morphine produced high titers of morphine- and heroinspecifc antibodies. The objective of this study was to determine if the antibodies generated by the M3-TT vaccine can reduce the antinociceptive efects induced by diferent doses of heroin or morphine. Female Balb-c mice were immunized with the M3-TT vaccine. A solid-phase antibody-capture ELISA was used to monitor antibody titer responses after each booster dose in vaccinated animals. The study used tail-fick and hot-plate testing to evaluate the antinociceptive efects of heroin or morphine. The M3-TT vaccine produced a specifc antibody titer of 1:450 000. The antibodies showed similar specifcity to heroin and morphine, which allowed reducing the antinociceptive efect of diferent doses of morphine and heroin. These features suggest that it is possible to use the vaccine as an adjuvant therapy that would maintain long-term abstinence in heroin-addicted patients.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.relation21:783-802
dc.rightsAcceso Cerradoes_ES
dc.titleThe M3‑TT Vaccine Decreases the Antinociceptive Efects of Morphine and Heroin in Micees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationSubdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, Ciudad de México, 14,370, México
dc.contributor.emailazazel_vamp@yahoo.com.mx
dc.relation.jnabreviadoINT J MENT HEALTH ADDICT
dc.relation.journalInternational Journal of Mental Health and Addiction
dc.identifier.placeEstados Unidos
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1557-1882
dc.identifier.doi10.1007/s11469-021-00621-z
dc.subject.kwVaccine
dc.subject.kwAddiction
dc.subject.kwHeroin
dc.subject.kwMorphine
dc.subject.kwActive vaccination
dc.subject.kwImmunotherapy


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