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Synergistic effect of estradiol and fluoxetine in young adult and middle-aged female rats in two models of experimental depression

dc.creatorRécamier-Carballo, Soledad
dc.creatorEstrada-Camarena, Erika
dc.creatorReyes, Rebeca
dc.creatorFernández-Guasti, Alonso
dc.date.accessioned2017-06-30T03:46:50Z
dc.date.available2017-06-30T03:46:50Z
dc.date.issued2012es_ES
dc.identifier2252es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6899
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2012.05.034es_ES
dc.language.isoenges_ES
dc.publisherElsevier B.V.es_ES
dc.relation233 (2) 351-358 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleSynergistic effect of estradiol and fluoxetine in young adult and middle-aged female rats in two models of experimental depressiones_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartament of Pharmacobiology, Center for Research and Advanced Studies (CINVESTAV), Mexicoes_ES
dc.contributor.emailjfernand@cinvestav.mxes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placeAmsterdanes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbr.2012.05.034es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaThe antidepressant effect of estrogens combined with antidepressants is controversial: some preclinical data showed that estrogens facilitate the effect of antidepressants in the forced swimming test (FST) in young adult rats, while others failed to find such effect in middle-aged rats in the chronic mild stress (CMS) model. In clinics similar differences were reported and may be due to the compounds, the depression model or type of depression, the experimental design, and the age of the subjects or the women’s menopause stage. The objective of this study was to analyze the antidepressant-like effect of the combination of 17_-estradiol (E2) and fluoxetine (FLX) in young adults (2–4 months) and middle-aged (12–14 months) ovariectomized (OVX) rats in two experimental models: FST and CMS. E2 (5 and 10 _g/rat) and FLX (2.5 and 10 mg/kg) per se dose-dependently reduced immobility in both age groups and, in young adults both compounds increased swimming, whereas in middle-aged rats they increased swimming and climbing. Analysis of the antidepressant-like effect of the combination of suboptimal doses of FLX (1.25 mg/kg) and E2 (2.5 _g/rat) showed a decrease in immobility and an increase in swimming in both age groups. In the CMS, chronic E2 (2.5 _g/rat) with FLX (1.25 mg/kg) augmented relative sucrose intake, but middle-aged rats responded 2 weeks earlier than young adults. These results show that the antidepressant-like effect of the combination of E2 and FLX in young adult and middle-aged female rats is evidenced in the two animal models of depression: FST and CMS.es_ES
dc.subject.kwFluoxetinaes_ES
dc.subject.kwPrueba de natación forzadaes_ES
dc.subject.kwRatas hembras adultas jóveneses_ES
dc.subject.kw17 -Estradioles_ES
dc.subject.kwEstrés leve crónicoes_ES
dc.subject.kwRatas hembra de mediana edades_ES
dc.subject.koFluoxetinees_ES
dc.subject.koForced swimming testes_ES
dc.subject.koYoung adult female ratses_ES
dc.subject.ko17 -Estradioles_ES
dc.subject.koChronic mild stresses_ES
dc.subject.koMiddle-aged female ratses_ES


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