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Long-term changes in sleep and electroencephalographic activity by chronic vagus nerve stimulation in cats

dc.creatorValdés-Cruz, Alejandro
dc.creatorMagdaleno-Madrigal, Víctor M.
dc.creatorMartínez-Vargas, David
dc.creatorFernández-Mas, Rodrigo
dc.creatorAlmazán-Alvarado, Salvador
dc.date.accessioned2017-06-30T03:44:47Z
dc.date.available2017-06-30T03:44:47Z
dc.date.issued2008es_ES
dc.identifier2211es_ES
dc.identifier.issn0278-5846es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6857
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2007.12.020es_ES
dc.language.isoenges_ES
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDes_ES
dc.relation32 (3) 828-834 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleLong-term changes in sleep and electroencephalographic activity by chronic vagus nerve stimulation in catses_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Neurofisiología del Control y la Regulación de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Secretaría de Salud, Méxicoes_ES
dc.contributor.emailalevalc@imp.edu.mxes_ES
dc.relation.jnabreviadoPROG NEUROPSYCHOPHARMACOL BIOL PSYCHIATRYes_ES
dc.relation.journalProgress in neuro-psychopharmacology & biological psychiatryes_ES
dc.identifier.placeOxfordes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1878-4216es_ES
dc.identifier.doi10.1016/j.pnpbp.2007.12.020es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaWe previously reported the effect of vagus nerve electrical stimulation (VNS) on sleep and behavior in cats. The aim of the present study is to analyze the long-term effects of VNS on the electroencephalographic (EEG) power spectrum and on the different stages of the sleep–wakefulness cycle in the freely moving cat. To achieve this, six male cats were implanted with electrodes on the left vagal nerve and submitted to 15 rounds of 23 h continuous sleep recordings in three categories: baseline (BL), VNS and post-stimulus recording (PSR). The following parameters were analyzed: EEG power spectrum, total time and number of sleep phases, ponto-geniculo-occipital (PGO) wave density of the rapid eye movement (REM) sleep, and the number of times the narcoleptic reflex was present (sudden transition from wakefulness to REM sleep). Significant changes were detected, such as an enhancement of slow-wave sleep (SWS) stage II; a power increase in the bands corresponding to sleep spindles (8–14 Hz) and delta waves (1–4 Hz) with VNS and PSR; an increase in the total time, number of stages, and density of PGO wave in REM sleep with VNS; a decrease of wakefulness in PSR, and the eventual appearance of the narcoleptic reflex with VNS. The results show that the effect of the VNS changes during different stages of the sleep–wakefulness cycle. In REM sleep, the effect was present only during VNS, while the SWS II was affected beyond VNS periods. This suggests that ponto-medullar and thalamic mechanisms of slow EEG activity may be due to plastic changes elicited by vagal stimulation.es_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmBehavior, Animal-Radiation effectses_ES
dc.subject.meshmCatses_ES
dc.subject.meshmDose-Response Relationship, Radiationes_ES
dc.subject.meshmElectric Stimulation-Methodses_ES
dc.subject.meshmElectroencephalographyes_ES
dc.subject.meshmFunctional Lateralityes_ES
dc.subject.meshmMalees_ES
dc.subject.meshmSleep-Physiologyes_ES
dc.subject.meshmSleep-Radiation effectses_ES
dc.subject.meshmSpectrum Analysises_ES
dc.subject.meshmTime Factorses_ES
dc.subject.meshmVagus Nerve-Physiologyes_ES
dc.subject.kwEspectro de potenciaes_ES
dc.subject.kwSueño REMes_ES
dc.subject.kwSueño de onda lentaes_ES
dc.subject.kwEstimulación del nervio vagoes_ES
dc.subject.koEEG activityes_ES
dc.subject.koPGO wavees_ES
dc.subject.koPower spectrumes_ES
dc.subject.koREM sleepes_ES
dc.subject.koSlow-wave sleepes_ES
dc.subject.koVagus nerve stimulationes_ES


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