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Ultrastructural changes and immunolocalization of P-selectin in platelets from patients with major depression

dc.creatorMendoza-Sotelo, José
dc.creatorTorner, Carlos
dc.creatorAlvarado-Vásquez, Noé
dc.creatorLazo-Langner, Alejandro
dc.creatorLópez, Guadalupe
dc.creatorArango, Iván
dc.creatorPavón, Lenin
dc.creatorGonzález-Trujano, Eva
dc.creatorMoreno, Julia
dc.date.accessioned2017-06-30T03:43:35Z
dc.date.available2017-06-30T03:43:35Z
dc.date.issued2010es_ES
dc.identifier2181es_ES
dc.identifier.issn0165-1781es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6829
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2009.07.021es_ES
dc.language.isoenges_ES
dc.publisherElsevier Ireland LTD, Elsevier House, Brookvale Plaza, East Park Shannon, CO, Clare, 00000, Ireland.es_ES
dc.relation176 (2-3) 179-182 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdolescentes_ES
dc.subject.meshAdultes_ES
dc.subject.meshBlood Platelets-Metabolismes_ES
dc.subject.meshBlood Platelets-Ultrastructurees_ES
dc.subject.meshDepressive Disorder, Major-Bloodes_ES
dc.subject.meshDepressive Disorder, Major-Pathologyes_ES
dc.subject.meshFemalees_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMicroscopy, Electron, Transmission-Methodses_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshP-Selectin-Metabolismes_ES
dc.titleUltrastructural changes and immunolocalization of P-selectin in platelets from patients with major depressiones_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Clin Lab, Calzada Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailmoreno@imp.edu.mxes_ES
dc.relation.jnabreviadoPSYCHIATRY RESes_ES
dc.relation.journalPsychiatry Researches_ES
dc.identifier.placeClare, Irelandes_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-7123es_ES
dc.identifier.doi10.1016/j.psychres.2009.07.021   es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaDepression is considered an important risk factor in patients with cardiovascular disease (CVD). Although the biological mechanism is unknown, it has been suggested that hyperactivity of platelets may have an important role in the onset and evolution of cardiovascular damage. The goals of this study were to evaluate by transmission electron microscopy and immunohistochemistry the presence of ultra-structural variations in platelets from individuals with recent diagnosis of major depression disease (MDD, patients without previous anti-depressant treatment and from healthy control subjects.). Platelets from depressed patients had a greater proportion of dendritic forms compared with those obtained from control subjects. Morphological changes, such as dilation of open canalicular and dense tubular systems, platelet vacuolization, electrodense pattern of membranes, and a different immunolocalization of P-selectin were observed in the platelets from depressed patients compared with those isolated from healthy subjects. Our results revealed ultra-structural changes in platelets isolated from patients with MDD suggestive of enhanced platelet activation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.es_ES
dc.subject.meshmPlasma factor(s)es_ES
dc.subject.meshmBlood-plateletses_ES
dc.subject.meshmAggregationes_ES
dc.subject.meshmDiseasees_ES
dc.subject.meshmInhibitiones_ES
dc.subject.meshmMechanismses_ES
dc.subject.meshmExpressiones_ES
dc.subject.meshmYoung Adultes_ES
dc.subject.kwTrastorno depresivo mayores_ES
dc.subject.kwPlaquetases_ES
dc.subject.kwP-selectinaes_ES
dc.subject.kwEnfermedad cardiovasculares_ES
dc.subject.kwMorfología plaquetariaes_ES
dc.subject.kwCoagulación sanguíneaes_ES
dc.subject.koMajor depressive disorderes_ES
dc.subject.koPlateletses_ES
dc.subject.koP-selectines_ES
dc.subject.koCardiovascular diseasees_ES
dc.subject.koPlatelet morphologyes_ES
dc.subject.koBlood coagulationes_ES


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