Mostrar el registro sencillo del ítem

Prepro-orexin and feeding-related peptide receptor expression in dehydration-induced anorexia

dc.creatorGarcía-Luna, C.
dc.creatorAmaya, M.I.
dc.creatorAlvarez-Salas, E.
dc.creatorDe Gortari, P.
dc.date.accessioned2017-06-30T01:39:43Z
dc.date.available2017-06-30T01:39:43Z
dc.date.issued2010es_ES
dc.identifier1508es_ES
dc.identifier.issn0167-0115es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6187
dc.identifier.urihttps://doi.org/10.1016/j.regpep.2009.09.011es_ES
dc.language.isoenges_ES
dc.relation159 (1-3) 54-60 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnorexia-Etiologyes_ES
dc.subject.meshAnorexia-Metabolismes_ES
dc.subject.meshDehydration-Complicationses_ES
dc.subject.meshDehydration-Metabolismes_ES
dc.subject.meshFeeding behaviores_ES
dc.subject.meshGene expression regulationes_ES
dc.subject.meshHypothalamo-Hypophyseal Systemes_ES
dc.subject.meshIntracellular Signaling Peptides and Proteins-Metabolismes_ES
dc.subject.meshLeptin-Metabolismes_ES
dc.subject.meshMalees_ES
dc.subject.meshMalnutrition-Metabolismes_ES
dc.subject.meshNeurons-Metabolismes_ES
dc.subject.meshNeuropeptide Y-Metabolismes_ES
dc.subject.meshNeuropeptides-Metabolismes_ES
dc.subject.meshParaventricular hypothalamic nucleus-Metabolismes_ES
dc.subject.meshPituitary-adrenal Systemes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, G-Protein-Coupled-Biosynthesises_ES
dc.subject.meshReceptors, Neuropeptide-Biosynthesises_ES
dc.subject.meshReceptors, Neuropeptide Y-Biosynthesises_ES
dc.subject.meshSignal transductiones_ES
dc.subject.meshThyrotropin-Biosynthesises_ES
dc.subject.meshThyrotropin-releasing hormone-Biosynthesises_ES
dc.subject.meshIntracellular signaling peptides and proteinses_ES
dc.subject.meshLeptines_ES
dc.subject.meshNeuropeptide Yes_ES
dc.subject.meshNeuropeptideses_ES
dc.subject.meshReceptors, G-Protein-Coupledes_ES
dc.subject.meshReceptors, Neuropeptidees_ES
dc.subject.meshReceptors, Neuropeptide Yes_ES
dc.subject.meshNeuropeptide Y-Y1 receptores_ES
dc.subject.meshOrexin receptorses_ES
dc.subject.meshOrexinses_ES
dc.subject.meshThyrotropin-releasing hormonees_ES
dc.subject.meshThyrotropines_ES
dc.titlePrepro-orexin and feeding-related peptide receptor expression in dehydration-induced anorexiaes_ES
dc.typearticlees_ES
dc.contributor.affiliationDirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría RFM, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, 14370 México D.F., Mexicoes_ES
dc.contributor.emailgortari@imp.edu.mxes_ES
dc.relation.jnabreviadoREGUL PEPTes_ES
dc.relation.journalRegulatory Peptideses_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-1686es_ES
dc.identifier.doi10.1016/j.regpep.2009.09.011es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaFood-restricted animals present metabolic adaptations that facilitate food-seeking behavior and decelerate energy utilization by reducing the hypothalamus-pituitary-thyroid (HPT) axis function. Stress by dehydration induces an anorexic behavior in rats, loss of weight and reduced food intake when compared to ad libitum fed animals, however these alterations are accompanied by HPT axis changes such as increased serum thyrotropin levels and enhanced expression of thyrotropin-releasing hormone (TRH) in the paraventricular nucleus of the hypothalamus, which is considered as anorexigenic peptide. In contrast, a pair-fed group conformed by forced-food-restricted animals (FFR) (eating the exact same amount of food as dehydration-induced anorexic rats--DIA rats) present decreased TRH mRNA levels. NPY synthesis in the arcuate nucleus and orexin-expressing neurons from the lateral hypothalamic area (LHA) are activated during food restriction. These brain structures project into PVN, suggesting that NPY and orexins are possible factors involved in TRHergic neuron activation in DIA rats. Leptin signaling is another likely factor to be involved in TRH differential expression. Therefore, to gain more insight into the regulation of the feeding behavior in the experimental models, we analyzed Y1, Y5, Ox1-R and Ob-R(b) mRNA levels in PVN and prepro-orexin in LHA, since their signaling to the PVN might be altering TRH synthesis and feeding in DIA animals. Prepro-orexinergic cells were activated in FFR animals; Ox1-R and Y1 expression was reduced in FFR vs. controls or DIA group. Compensatory changes in PVN receptor expression of some feeding-related peptides in anorexic rats may alter TRHergic neural response to energy demands.es_ES
dc.subject.kwHormona liberadora de tirotropina (HLT)es_ES
dc.subject.kwNPYes_ES
dc.subject.kwLeptinaes_ES
dc.subject.kwÁrea hipotalámica laterales_ES
dc.subject.kwNúcleo paraventriculares_ES
dc.subject.koTRHes_ES
dc.subject.koNPYes_ES
dc.subject.koLeptines_ES
dc.subject.koLateral hypothalamic areaes_ES
dc.subject.koParaventricular nucleuses_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem