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Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts

dc.creatorMartínez, Ana L.
dc.creatorGonzález-Trujano, María Eva
dc.creatorPellicer, Francisco
dc.creatorLópez-Muñoz, Francisco J.
dc.creatorNavarrete, Andrés
dc.date.accessioned2017-06-30T01:36:53Z
dc.date.available2017-06-30T01:36:53Z
dc.date.issued2009es_ES
dc.identifier1485es_ES
dc.identifier.issn0032-0943es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6166
dc.identifier.urihttp://doi.org/10.1055/s-0029-1185319es_ES
dc.language.isoenges_ES
dc.relation75 (5) 508-511 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnalgesics-Chemistryes_ES
dc.subject.meshAnalgesics-Pharmacologyes_ES
dc.subject.meshAnalgesics-Therapeutic usees_ES
dc.subject.meshAnimalses_ES
dc.subject.meshArthritis-Chemically inducedes_ES
dc.subject.meshArthritis-Drug therapyes_ES
dc.subject.meshChromatography, Gases_ES
dc.subject.meshMalees_ES
dc.subject.meshMass Spectrometryes_ES
dc.subject.meshNaloxone-Phamacologyes_ES
dc.subject.meshNarcotic antagonists-Pharmacologyes_ES
dc.subject.meshOils, volatile-Chemistryes_ES
dc.subject.meshOils, volatile-Phamacologyes_ES
dc.subject.meshOils, volatile-Therapeutic usees_ES
dc.subject.meshPain-Chemically inducedes_ES
dc.subject.meshPain-Drug therapyes_ES
dc.subject.meshPiperazines-Phamacologyes_ES
dc.subject.meshPlant components, Aeriales_ES
dc.subject.meshPlant extracts-Chemistryes_ES
dc.subject.meshPlant extracts-Phamacologyes_ES
dc.subject.meshPlant extracts-Tharapeutic usees_ES
dc.subject.meshPyridines-Pharmacologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshRosmarinus-Chemistryes_ES
dc.subject.meshSerotonin antagonists-Phamacologyes_ES
dc.subject.meshTerpenes-Isolation & purificationes_ES
dc.subject.meshUric acid-Adverse effectses_ES
dc.subject.meshAnalgesicses_ES
dc.subject.meshNarcotic antagonistses_ES
dc.subject.meshOils, volatilees_ES
dc.subject.meshPiperazineses_ES
dc.subject.meshPlant extractses_ES
dc.subject.meshPyridineses_ES
dc.subject.meshSerotonin antagonistses_ES
dc.subject.meshTerpeneses_ES
dc.subject.meshNaloxonees_ES
dc.subject.meshUric acides_ES
dc.subject.meshN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidees_ES
dc.titleAntinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial partses_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, D. F., México.es_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.relation.jnabreviadoPLANTA MEDes_ES
dc.relation.journalPlanta Medicaes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1439-0221es_ES
dc.identifier.doi10.1055/s-0029-1185319es_ES
dc.description.abstractotrodiomaThe rationale of this investigation was to examine the antinociceptive properties of the essential oil obtained from Rosmarinus officinalis aerial parts, using a rat model of arthritic pain. The essential oil (100, 300 and 600 mg-kg, I. P.) produced a dose-dependent antinociceptive effect, manifested as a significant reduction in the dysfunction in the pain-induced functional impairment model in the rat (PIFIR model), mainly at high doses. Chemical constituents of the essential oil were further analyzed by gas chromatography-mass spectrometry (GC-MS). The major compounds in the essential oil were alpha-pinene (14.10 %), camphene (11.47 %), beta-pinene (12.02 %), myrcene (3.31 %), alpha-phellandrene (7.87 %), eucalyptol (8.58 %), 2-bornanone (3.42 %), camphor (8.75 %), isoborneol (3.48 %), borneol (4.85 %) and borneol acetate (6.49 %). The antinociceptive effects of R. officinalis essential oil were tested in combination with 0.12 mg-kg WAY100635, s. c. (an antagonist of 5-HT(1A) receptors) or 1 mg-kg naloxone, i. p. (an antagonist of endogenous opioids receptors), demonstrating in both cases an inhibition of the antinociceptive response. This study suggests an involvement, at least in part, of the serotonergic system via 5-HT(1A) receptors and endogenous opioids in the antinociceptive effect of R. officinalis essential oil in the PIFIR model.es_ES
dc.subject.kwAntinocicepciónes_ES
dc.subject.kwOpioides endógenoses_ES
dc.subject.kwEnsayo PIFIRes_ES
dc.subject.kwReceptores 5 HT1Aes_ES
dc.subject.kwRosmarinus officinalis L.es_ES
dc.subject.kwLamiaceaees_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koEndogenous opioidses_ES
dc.subject.koPIFIR assayes_ES
dc.subject.ko5 HT1A receptorses_ES
dc.subject.koRosmarinus officinalis L.es_ES
dc.subject.koLamiaceaees_ES


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