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Effect of 8-OH-DPAT on electrographic activity during the kainic acid-induced status epilepticus in rats

dc.creatorLópez-Meraz, María Leonor
dc.creatorMartínez, Adrián
dc.creatorRocha, Luisa
dc.date.accessioned2017-06-30T01:35:22Z
dc.date.available2017-06-30T01:35:22Z
dc.date.issued2007es_ES
dc.identifier1474es_ES
dc.identifier.issn1059-1311es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6155
dc.identifier.urihttps://doi.org/10.1016/j.seizure.2007.02.009es_ES
dc.language.isoenges_ES
dc.relation16 (4) 365-370 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffect of 8-OH-DPAT on electrographic activity during the kainic acid-induced status epilepticus in ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados Sede Sur, Mexico City, Mexico.es_ES
dc.contributor.emaillopezmerazml@ucla.edues_ES
dc.relation.jnabreviadoSEIZUREes_ES
dc.relation.journalSeizurees_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2007es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1532-2688es_ES
dc.identifier.doi10.1016/j.seizure.2007.02.009es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaThe effect of 8-OH-DPAT, a 5-HT1A receptor agonist, on electrographic activity during the kainic acid (KA)-induced status epilepticus (SE) was evaluated in male Wistar rats. Electrographic (EEG) recordings from the ventral hippocampus and the frontal cortex along with behavioral changes were evaluated in animals that received KA administration (10mg-kg, i.p.) 20 min after saline solution (control group) or 8-OH-DPAT (1mg-kg, s.c.) injection. Rats pretreated with 8-OH-DPAT presented augmented latency for wet dog shakes (71%), generalized seizures (54%) and behavioral SE (31%). 8-OH-DPAT delayed occurrence of the first KA-induced paroxystic spikes (70%), increased latency to the EEG SE (39%) and decreased spike frequency (35-43%) recorded from the frontal cortex, and increased the time necessary for the high voltage EEG activity synchronization of the hippocampus and the frontal cortex (125%). However, EEG ictal activity recorded in hippocampus was not modified after 8-OH-DPAT pretreatment. These results indicate that 8-OH-DPAT reduces the EEG activity associated with the KA-induced SE in the frontal cortex, but not the hippocampus, and suggest an inhibitory effect in the propagation of epileptic seizures during the KA-induced SE.es_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koBraines_ES
dc.subject.kodrug effectses_ES
dc.subject.koElectroencephalographyes_ES
dc.subject.kodrug effectses_ES
dc.subject.koExcitatory Amino Acid Agonistses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koKainic Acides_ES
dc.subject.kopharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koSerotonin Receptor Agonistses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koStatus Epilepticuses_ES
dc.subject.kochemically inducedes_ES
dc.subject.koStatus Epilepticuses_ES
dc.subject.kophysiopathologyes_ES
dc.subject.koExcitatory Amino Acid Agonistses_ES
dc.subject.koSerotonin Receptor Agonistses_ES
dc.subject.koKainic Acides_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES


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