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Anxiolytic-like actions of testosterone in the burying behavior test: role of androgen and GABA-benzodiazepine receptors

dc.creatorFernández-Guasti, Alonso
dc.creatorMartínez-Mota, Lucía
dc.date.accessioned2017-06-30T01:33:00Z
dc.date.available2017-06-30T01:33:00Z
dc.date.issued2005es_ES
dc.identifier1456es_ES
dc.identifier.issn0306-4530es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.psyneuen.2005.03.006es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6137
dc.language.isoenges_ES
dc.relation30 (8) 762-770 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnxiolytic-like actions of testosterone in the burying behavior test: role of androgen and GABA-benzodiazepine receptorses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacobiología Centro de Investigación y Estudios Avanzados del IPN, Col. Granjas Coapa Tlalpan, México.es_ES
dc.contributor.emailjfernand@mail.cinvestav.mxes_ES
dc.relation.jnabreviadoPSYCHONEUROENDOCRINOLOGYes_ES
dc.relation.journalPsychoneuroendocrinologyes_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2005es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-3360es_ES
dc.identifier.doi10.1016/j.psyneuen.2005.03.006es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaThe first objective of the present study was to explore if several androgens, including testosterone propionate (TP) and its reduced metabolites, 5alpha-androstan-3alpha, 17beta-diol (3alpha-androstanediol) and 5alpha-androstan-3alpha-ol-17-one (androsterone), produce an anxiolytic-like effect in the burying behavior paradigm. Additionally, the possible participation of androgen or GABA(A)-benzodiazepine receptors in the anxiolytic-like effect of TP was analyzed. Orchidectomized male rats were treated with four injections of TP (0.25, 0.50, 1.0 mg-rat), 3alpha-androstanediol or androsterone (0.5 and 1.0 mg-rat), and the cumulative burying (denoting anxiety levels) and burying behavior latency (reflecting reactivity) evaluated. Besides, a single injection (0.5 mg-rat, -30 m) of each androgen was also tested in castrated rats. Repeated treatment with TP (0.5 and 1.0 mg-rat), but not a single injection of this androgen, produced an anxiolytic-like effect without changes on reactivity. Neither repeated- nor single-treatment with 3alpha-androstanediol nor androsterone produced a reduction of anxiety-like behavior. For the experiment studying the TP mechanism of action, this androgen (0.5 mg-rat, four injections) was combined with an antagonist for androgen receptors, flutamide (50 mg-kg, SC, 7 injections), or with a benzodiazepine antagonist, flumazenil (15 mg-kg, IP, -30 m). Flutamide, but not flumazenil, blocked the anxiolytic-like effects produced by TP. Results are discussed on the basis of interaction of these steroids with androgen receptors or GABA(A)-benzodiazepine receptorses_ES
dc.subject.koAndrogen Antagonistses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koAnxietyes_ES
dc.subject.kometabolismes_ES
dc.subject.koBehavior, Animales_ES
dc.subject.kodrug effectses_ES
dc.subject.koBehavior, Animales_ES
dc.subject.kophysiologyes_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koDrug Administration Schedulees_ES
dc.subject.koFlumazeniles_ES
dc.subject.kopharmacologyes_ES
dc.subject.koFlutamidees_ES
dc.subject.kopharmacologyes_ES
dc.subject.koGABA Modulatorses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koMotor Activityes_ES
dc.subject.kodrug effectses_ES
dc.subject.koMotor Activityes_ES
dc.subject.kophysiologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koReaction Timees_ES
dc.subject.kodrug effectses_ES
dc.subject.koReaction Timees_ES
dc.subject.kophysiologyes_ES
dc.subject.koReceptors, Androgenes_ES
dc.subject.kophysiologyes_ES
dc.subject.koReceptors, GABA-Aes_ES
dc.subject.kophysiologyes_ES
dc.subject.koTestosteronees_ES
dc.subject.koadministration & dosagees_ES
dc.subject.koTestosteronees_ES
dc.subject.kometabolismes_ES
dc.subject.koAndrogen Antagonistses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koGABA Modulatorses_ES
dc.subject.koReceptors, Androgenes_ES
dc.subject.koReceptors, GABA-Aes_ES
dc.subject.koFlutamidees_ES
dc.subject.koTestosteronees_ES
dc.subject.koFlumazeniles_ES


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