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Reduction in the latency of action of antidepressants by 17 _-estradiol in the forced swimming test

dc.contributor.advisor
dc.creatorEstrada-Camarena, E.
dc.creatorRivera, N.M.
dc.creatorBerlanga, C.
dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-29T06:03:41Z
dc.date.available2017-06-29T06:03:41Z
dc.date.issued2008es_ES
dc.identifier592es_ES
dc.identifier.issn0033-3158es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/5276
dc.identifier.urihttps://doi.org/10.1007/s00213-008-1291-8es_ES
dc.language.isoenges_ES
dc.relation201 (3) 351-360 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdrenergic uptake inhibitors-Pharmacologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive agents, second generation-Pharmacologyes_ES
dc.subject.meshBehavior, animal-Drug effectses_ES
dc.subject.meshCyclohexanols-Pharmacologyes_ES
dc.subject.meshDesipramine-Pharmacologyes_ES
dc.subject.meshDisease models, animales_ES
dc.subject.meshDose-response relationship, druges_ES
dc.subject.meshDrug therapy, combination estradiol-Pharmacologyes_ES
dc.subject.meshEstrogens-Pharmacologyes_ES
dc.subject.meshFemalees_ES
dc.subject.meshFluoxetine-Pharmacologyes_ES
dc.subject.meshInjections, subcutaneouses_ES
dc.subject.meshMotor activity-Drug effectses_ES
dc.subject.meshMotor activity-Physiologyes_ES
dc.subject.meshOvariectomyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReaction time-Drug effectses_ES
dc.subject.meshSerotonin uptake inhibitors-Pharmacologyes_ES
dc.subject.meshSwimming-Physiologyes_ES
dc.subject.meshSwimming-Psychologyes_ES
dc.titleReduction in the latency of action of antidepressants by 17 _-estradiol in the forced swimming testes_ES
dc.typearticlees_ES
dc.contributor.affiliationFarmacología Conductual Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñíz, México City, Mexico.es_ES
dc.relation.jnabreviadoPSYCHOPHARMACOLOGYes_ES
dc.relation.journalPsychopharmacologyes_ES
dc.identifier.placeGermanyes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1432-2072es_ES
dc.identifier.doi10.1007/s00213-008-1291-8es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaRATIONALE: Antidepressants (ADs) are slow to produce their therapeutic effect. This long latency promotes the development of new strategies to short their onset of action. Previous reports indicated that 17beta-estradiol (E(2)) promotes the antidepressant-like activity of fluoxetine (FLX) and desipramine (DMI) in the forced swimming test (FST). OBJECTIVE: The aim of the present work was to analyze if E(2) reduces the antidepressant-like onset of action of venlafaxine (VLX), FLX, and DMI. MATERIALS AND METHODS: Independent groups of ovariectomized female Wistar rats were tested in the FST and in the open field after chronic (1 to 14 days) treatment with VLX (20 mg-kg-day), FLX (1.25 mg-kg-day), or DMI (1.25 mg-kg-day) alone or in combination with a single injection of E(2) (2.5 microg-rat sc, 8 h before FST). RESULTS: VLX, FLX, or DMI by themselves at these doses did not induce changes in the FST at short intervals after their injection (from 1 to 7 days). The addition of E(2) promoted the antidepressant-like effect of VLX and DMI as early as day 1. Such action was also evident after 3, for FLX, and 14 days for both FLX and DMI, but not for VLX. The behavioral actions of these ADs combined with E(2) were not accompanied by increases in general activity in the open-field test. CONCLUSION: E(2) clearly reduced the latency to the onset of action for these ADs in the FST. These results represent an interesting therapeutic strategy for the treatment of depression in perimenopausal women.es_ES
dc.subject.kw17_-estradioles_ES
dc.subject.kwFluoxetinaes_ES
dc.subject.kwDesipraminaes_ES
dc.subject.kwVenlafaxinaes_ES
dc.subject.kwPrueba de nado forzadoes_ES
dc.subject.kwInicio de la acción más pequeñaes_ES
dc.subject.ko17_-Estradioles_ES
dc.subject.koVenlafaxinees_ES
dc.subject.koForced swimming testes_ES
dc.subject.koShorter onset of actiones_ES
dc.subject.koFluoxetinees_ES
dc.subject.koDesipraminees_ES


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