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Modification of the Anxiolytic Action of 5-HT 1A Compounds by GABA–Benzodiazepine Agents in Rats

dc.creatorFernández-Guasti, A.
dc.creatorLópez-Rubalcava, C.
dc.date.accessioned2017-06-29T04:21:30Z
dc.date.available2017-06-29T04:21:30Z
dc.date.issued1998es_ES
dc.identifier264es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4958
dc.identifier.urihttps://doi.org/10.1016/S0091-3057(97)00482-6es_ES
dc.language.isoenges_ES
dc.relation60 (1) 27-31 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleModification of the Anxiolytic Action of 5-HT 1A Compounds by GABA–Benzodiazepine Agents in Ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., Méxicoes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeTarrytow NYes_ES
dc.date.published1998es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaThe general purpose of the present study was to analyze the possible interactions between the GABA–benzodiazepine and the serotonin systems in the mediation of the antianxiety actions of 5-HT 1A compounds. The anxiolytic effect of buspirone (5 mg/kg), ipsapirone (5 mg/kg), indorenate (5 mg/kg), and 8-OH-DPAT (0.5 mg/kg) was established in the rat burying behavior test. Flumazenil (5 mg/kg), but not bicuculline (2.5 mg/kg), effectively counteracted the reduction in burying behavior produced by buspirone, ipsapirone, and 8-OH-DPAT. These same 5-HT 1A compounds, at subthreshold doses, produced an important reduction in burying behavior when combined with diazepam (0.25 mg/kg). The effect of indorenate was not altered by any of the antagonists and, when combined with diazepam it produced large increases in burying behavior latency. Only buspirone alone and in combination with bicuculline or lumazenil impaired motor coordination as tested in the rota rod. Data are discussed on the bases of the interaction between the GABAergic and serotonergic systems, stressing species differences and variations due to the animal model of anxiety.es_ES
dc.subject.kwRatases_ES
dc.subject.kwComportamiento de enterrares_ES
dc.subject.kw5-HT1A ligandoses_ES
dc.subject.kwFlumazenil itoes_ES
dc.subject.kwGABA-interacciones serotoninaes_ES
dc.subject.koRates_ES
dc.subject.koBurying behaviores_ES
dc.subject.ko5-HT1A ligandses_ES
dc.subject.koFlumazenil bicucullinees_ES
dc.subject.koGABA–serotonin interactionses_ES


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