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8-OH-DPAT and male rat sexual behavior: partial blockade by noradrenergic lesion and sexual exhaustion

dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-29T04:20:37Z
dc.date.available2017-06-29T04:20:37Z
dc.date.issued1997es_ES
dc.identifier249es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/S0091-3057(96)00165-7es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4943
dc.language.isoenges_ES
dc.relation56 (1) 111-116 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.title8-OH-DPAT and male rat sexual behavior: partial blockade by noradrenergic lesion and sexual exhaustiones_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, México and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México, D. F.es_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1997es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/S0091-3057(96)00165-7es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaAs previously shown, the 5-HT1A agonist 8-OH-DPAT is a potent facilitator of male rat copulatory behavior in both sexually experienced and sexually exhausted male rats. The basis of this facilitation is still not clear. Therefore, the purpose of the present study was to determine whether 8-OH-DPAT-induced sexual-behavior facilitation could be counteracted by lesioning the NA system with the noradrenergic neurotoxin DSP4. In NA-lesioned, sexually experienced, non-exhausted rats, the facilitatory effects of 8-OH-DPAT on the number of mounts and the postejaculatory interval were reduced, the effect on the intromission latency disappeared, while the percentage of copulating rats was not significantly altered. In sexually exhausted rats bearing a lesion of the NA system, the facilitatory effects of 8-OH-DPAT on the percentage of copulating rats was blocked. Data are discussed on the basis of the interactions between the noradrenergic and serotonergic systems in the mediation of the facilitatory effect of 8-OH-DPAT in sexually exhausted and non-exhausted ratses_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralin-Pharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koBenzylamineses_ES
dc.subject.koBrain Chemistry-Drug effectses_ES
dc.subject.koCopulation-Drug effectses_ES
dc.subject.koEjaculation-Drug effectses_ES
dc.subject.koMalees_ES
dc.subject.koNeurotoxinses_ES
dc.subject.koNorepinephrine-Metabolismes_ES
dc.subject.koNorepinephrine-Physiologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koSerotonines_ES
dc.subject.koReceptor Agonists-Pharmacologyes_ES
dc.subject.koSexual Behavior, Animal-Drug effectses_ES
dc.subject.koSympathectomy, Chemicales_ES
dc.subject.koSympathetic Nervous System-Drug effectses_ES
dc.subject.koSympathetic Nervous System-Physiologyes_ES
dc.subject.koBenzylamineses_ES
dc.subject.koNeurotoxinses_ES
dc.subject.koSerotonin Receptor Agonistses_ES
dc.subject.koNorepinephrinees_ES
dc.subject.koDSP 4es_ES
dc.subject.ko8-Hydroxy-2-(di-n-propylamino)tetralines_ES


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