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Interaction of GABA and Serotonin in the Anxiolytic Action of Diazepam and Serotonergic Anxiolytics

dc.creatorLópez-Rubalcava, C.
dc.creatorSaldívar, A.
dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-29T04:15:50Z
dc.date.available2017-06-29T04:15:50Z
dc.date.issued1992es_ES
dc.identifier137es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4831
dc.identifier.urihttps://doi.org/10.1016/0091-3057(92)90173-Des_ES
dc.language.isoenges_ES
dc.relation43 (2) 433-440 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleInteraction of GABA and Serotonin in the Anxiolytic Action of Diazepam and Serotonergic Anxiolyticses_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, y División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., Méxicoes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeTarrytown, N.Y.es_ES
dc.date.published1992es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaThe general purpose of the present study was to analyze the possible interactions between the GABA-benzodiazepine and the serotonergic (5-HT) systems in the anxiolytic action of diazepam and the 5-HTI^ agonists, ipsapirone, indorenate, and 8-hydroxy-2-(di-n-propylamino)tetralin( 8-OH-DPAT). The effect of the benzodiazepine receptor antagonist, flumazenil (10.0 rag/kg), on the anxiolytic action of ipsapirone (5.0 mg/kg), indorenate (5.0 rag/kg), and 8-OH-DPAT (0.125 mg/kg) was examined on the avoidance exploratory behavior paradigm in mice. The effect of the 5-HTI blockers, methiotepin (0.31 rag/kg), pindolol (3.1 mg/kg), and alprenolol (5.0 mg/kg), on the anxiolytic action of diazepam (0.5 mg/kg) was also studied. In the last part of this work, the putative potentiation between diazepam (0.25 mg/kg) and each of the serotonergic anxiolytics was investigated. The antianxiety effect of diazepam, ipsapirone, indorenate, and 8-OH-DPAT was prevented by flumazenil. The serotonergic//~-blocker, alprenolol, partially antagonized the diazepam effect. Finally, a potentiation of suboptimal doses of diazepam and ipsapirone, but not with indorenate or 8-OH-DPAT, was observed. The findings suggest an interaction between both systems on the anxiolytic action of diazepam and the 5-HT~A agonists.es_ES
dc.subject.kw5-HT de ansiolíticoses_ES
dc.subject.kwDiazepames_ES
dc.subject.kwFlumazeniles_ES
dc.subject.kw5-HT1es_ES
dc.subject.kwBeta bloqueadoreses_ES
dc.subject.kwGABA- 5-HT interaccioneses_ES
dc.subject.kwAnsiedades_ES
dc.subject.ko5-HT1A- anxiolyticses_ES
dc.subject.koDiazepames_ES
dc.subject.koFlumazeniles_ES
dc.subject.ko5-HT1es_ES
dc.subject.koBeta-blockerses_ES
dc.subject.koGABA-5-HT interactionses_ES
dc.subject.koAnxietyes_ES


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