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The actions of diazepam and serotonergic anxiolytics vary according to the gender and the estrous cycle phase

dc.creatorFernández-Guasti, A.
dc.creatorPicazo, O.
dc.date.accessioned2017-06-29T04:14:48Z
dc.date.available2017-06-29T04:14:48Z
dc.date.issued1990es_ES
dc.identifier101es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0091-3057(90)90044-Ies_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4796
dc.language.isoenges_ES
dc.relation37 (1) 77-81 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleThe actions of diazepam and serotonergic anxiolytics vary according to the gender and the estrous cycle phasees_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México.es_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology Biochemistry and Behaviores_ES
dc.identifier.placeEstados Inidoses_ES
dc.date.published1990es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/0091-3057(90)90044-Ies_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaThe anxiolytic effect of diazepam (0.5, 1.0 and 2.0 mg-kg), buspirone (2.5 and 5.0 mg-kg) indorenate (2.5 and 5.0 mg-kg) and ipsapirone (5.0 and 10.0 mg-kg) was evaluated in male and female rats during the proestrus and metestrus phases. The burying behavior test was used to measure the anxiety levels. In this test, increases in the behavior latency are interpreted as prolonged reactivity, while reductions in the burying behavior are considered to reflect anxiolytic states. Diazepam increases in burying behavior latency were consistently higher than those observed after serotonergic anxiolytics. Buspirone, at no dose tested, affected the burying behavior latency, while indorenate and ipsapirone had only minor effects. Male individuals were more sensitive than females to the actions of diazepam on burying behavior. The serotonergic anxiolytics produce similar responses in both sexes. Metestrus females were much less sensitive to the action of all anxiolytics on burying behavior latency than proestrus females. Proestrus females were highly sensitive to the actions of diazepam on burying latency as compared both with males and metestrus females. Data show that a larger gender and within females variation occurs after treatment with diazepam as compared with the serotogergic anxiolytics. The results are discussed considering the relationships between ovarian hormones and the GABA-benzodiazepinic and serotonergic systems.es_ES
dc.subject.kwBurying behaviores_ES
dc.subject.kwDiazepames_ES
dc.subject.kwGender differenceses_ES
dc.subject.kwSerotonergic anxiolyticses_ES
dc.subject.kwEstrous cycle phase differenceses_ES
dc.subject.ko5-Methoxytryptamine-Analogs & derivativeses_ES
dc.subject.ko5-Methoxytryptamine-Pharmacologyes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koBehavior, Animales_ES
dc.subject.koBuspirone-Drug effectses_ES
dc.subject.koDiazepames_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koFemalees_ES
dc.subject.koMalees_ES
dc.subject.koMetestrus-Physiologyes_ES
dc.subject.koProestruses_ES
dc.subject.koPyrimidineses_ES
dc.subject.koRatses_ES
dc.subject.koRats, Inbred Strainses_ES
dc.subject.koReaction Timees_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koSex Factorses_ES
dc.subject.koSubstanceses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koReceptors, Serotonines_ES
dc.subject.koDiazepames_ES
dc.subject.ko5-Methoxytryptaminees_ES
dc.subject.koIpsapironees_ES
dc.subject.koIndorenatees_ES


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