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Increased myo-inositol in the posterior cingulate cortex in first-episode major depressive patients

dc.creatorGranados-Domínguez, Lily Magally
dc.creatorFlores-Gutiérrez, Enrique O.
dc.creatorAlcauter, Sarael
dc.creatorCervantes, Juan José
dc.creatorTorres-Álvarez, Marina
dc.creatorCorsi-Cabrera, María
dc.date.accessioned2017-06-29T03:53:28Z
dc.date.available2017-06-29T03:53:28Z
dc.date.issued2013es_ES
dc.identifier2762es_ES
dc.identifier.issn2156-8456es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4611
dc.identifier.urihttp://doi.org/10.4236/abb.2013.46A007es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherIrvine, CA : Scientific Research Publishing, Inc.es_ES
dc.relation4, 45-52 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleIncreased myo-inositol in the posterior cingulate cortex in first-episode major depressive patientses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratory for Sleep Research, Faculty of Psychology, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexicoes_ES
dc.contributor.emailcorsi@unam.mxes_ES
dc.relation.jnabreviadoADV BIOSCI BIOTECHNOLes_ES
dc.relation.journalAdvances in Bioscience and Biotechnologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn2156-8502es_ES
dc.identifier.doi10.4236/abb.2013.46A007es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaMajor depressive disorder (MDD) is a severe, disabling pathology characterized, in addition to affective, cognitive and motor symptoms, by self-focused attention and rumination. During recursive self-focused processes and rumination, the posterior cingulate cortex (PCC) is activated. In vivo proton magnetic resonance spectroscopy (MRS) is a noninvasive imaging technique that can directly assess living biochemistry in localized brain regions. The aim of this study, therefore, was to use 1 H-MRS as a means of analyzing brain metabolites in the PCC of a group of first-episode, unmedicated MDD patients. PCC metabolite levels were analyzed at 3-T in a single voxel located bilaterally over the PCC in 7 patients diagnosed for the first time with MDD and with no previous pharmacological treatment, as well as in 9 control subjects. Differences in metabolite levels between groups were compared using independent t-tests. Myo-inositol was significantly higher, and NAA + NAAG/Cr significantly lower, in MDD patients than in controls. The other brain metabolites showed no statistical differences. The present results suggest that alterations in PCC metabolite levels are likely involved in MDD pathophysiology, and may help to improve our understanding of MDD and the role of the PCC in some symptoms of depression.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koMajor depressive disorderes_ES
dc.subject.koPosterior cingulate Cortexes_ES
dc.subject.koMetaboliteses_ES
dc.subject.ko1 H-MRSes_ES
dc.subject.koMyo-Inositoles_ES
dc.subject.koN-Acetyl-Aspartatees_ES


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