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Gray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM study

dc.creatorAlcauter, Sarael
dc.creatorBarrios, Fernando A.
dc.creatorDíaz, Rosalinda
dc.creatorFernández-Ruiz, Juan
dc.date.accessioned2017-06-29T03:51:49Z
dc.date.available2017-06-29T03:51:49Z
dc.date.issued2011es_ES
dc.identifier2741es_ES
dc.identifier.issn1053-8119es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4590
dc.language.isoenges_ES
dc.publisherOrlando, FL : Academic Press, c1992-es_ES
dc.relation55 (1) 1-7 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleGray and white matter alterations in spinocerebellar ataxia type 7: An in vivo DTI and VBM studyes_ES
dc.typeartículoes_ES
dc.contributor.affiliationUniversidad Nacional Autónoma de México, Instituto de Neurobiologíaes_ES
dc.contributor.emailalcauter@inb.unam.mxes_ES
dc.relation.jnabreviadoNEUROIMAGEes_ES
dc.relation.journalNeuroImagees_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1095-9572es_ES
dc.identifier.doi10.1016/j.neuroimage.2010.12.014es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaSpinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder characterized by cerebellar ataxia and visual loss. It is caused by a CAG repeat expansion in the gene encoding the ataxin 7 protein. Visual loss is due to a progressive atrophy of photoreceptor cells that results in macular degeneration in more advanced stages. Initial semiautomatic measures in magnetic resonance imaging (MRI) studies on the brain stem have shown a diminished volume mainly in the cerebellum and pons, while T2 images have shown hyperintensities in transverse fibers at the pons. Neuropathological research, however, has shown more widespread brain damage including loss of myelinated fibers. In this study we decided to take advantage of recent MRI methodological advances to further explore the gray and white matter changes that occur in SCA7 patients. We studied nine genetically confirmed SCA7 patients and their matched controls using voxel based morphometry and tract-based spatial statistics. As expected, we found significant bilateral gray matter volume reductions (p < 0.05, corrected for multiple comparisons) in patients' cerebellar cortex. However, we also found significant bilateral gray matter reductions in pre and postcentral gyrus, inferior and medial frontal, parietal inferior, parahippocampal and occipital cortices. The analysis also showed a decrement in fractional anisotropy (p < 0.05, corrected) of SCA7 patients in the cerebellum's white matter, brainstem, cerebellar and cerebral peduncles, midbrain, anterior and posterior internal capsule, external-extreme capsule, corpus callosum, corona radiata, optical radiations, and the occipital, temporal and frontal lobe's white matter. These results confirm previous evidence of widespread damage beyond the cerebellum and the pons in SCA7 patients. They also confirmed previous results that had been only detectable through neuropathological analyses and, more importantly, identified new regions affected by the disease that previous methods could not detect. These new results could help explain the symptom's spectrum that affects these patients.es_ES
dc.subject.koSpinocerebellar ataxiaes_ES
dc.subject.koSCA7es_ES
dc.subject.koVoxel based morphometryes_ES
dc.subject.koDiffusion tensor imaginges_ES
dc.subject.koTract-based spatial statisticses_ES
dc.subject.koCAGes_ES


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