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Effect of sub-optimal doses of fluoxetine plus estradiol on antidepressant-like behavior and hippocampal neurogenesis inovariectomized rats

dc.creatorVega-Rivera, Nelly M.
dc.creatorFernández-Guasti, Alonso
dc.creatorRamírez-Rodríguez, Gerardo
dc.creatorEstrada-Camarena, Erika
dc.date.accessioned2017-06-29T03:46:42Z
dc.date.available2017-06-29T03:46:42Z
dc.date.issued2015es_ES
dc.identifier2665es_ES
dc.identifier.issn0306-4530es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.psyneuen.2015.03.022es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4514
dc.language.isoenges_ES
dc.relation57 113-124p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffect of sub-optimal doses of fluoxetine plus estradiol on antidepressant-like behavior and hippocampal neurogenesis inovariectomized ratses_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratory of Neuropsychopharmacology, Division of Neurosciences, National Institute of Psychiatry,México, D.F., Mexicoes_ES
dc.contributor.emailestrada@imp.edu.mx, monesca71@gmail.comes_ES
dc.relation.jnabreviadoPSYCHONEUROENDOCRINOLOGYes_ES
dc.relation.journalPsychoneuroendocrinologyes_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2015es_ES
dc.identifier.eissn1873-3360es_ES
dc.identifier.doi10.1016/j.psyneuen.2015.03.022es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaEstrogens and antidepressants synergize to reduce depressive symptoms and stimulate neurogenesis and neuroplastic events. The aim of this study was to explore whether the antidepressant-like effect induced by the combination of low doses of estradiol (E2) and flu-oxetine (FLX) involves changes in cell proliferation, early survival, morphology and dendrite complexity of hippocampal new-immature neurons. The antidepressant-like effects of E2and/or FLX were evaluated by the forced swimming test(FST), cell proliferation was determined with the endogenous marker Ki67, survival of newborn cells was established with bromo-deoxiuridine (BrdU) and immature neurons were as curtained by doublecortin (DCX) labeling while their dendrite complexity was evaluated with Sholl analy-sis. Ovariectomized Wistar rats were randomly assigned to one of the following groups: Vehicle(saline/14 days + Oil/−8 h before FST); E2(saline/14 days + E22.5 or 10  _g/rat; −8 h before FST); FLX (1.25 or 10 mg/kg for 14 days + oil −8 h before FST), and FLX plus E2(FLX 1.25 mg/kgfor 14 days + E22.5  _g/rat −8 h before FST).The combination of sub-threshold doses of FLX plus E2 produced antidepressant-like actions similar to those induced by FLX or E2 given independently at optimal doses. Only FLX at an optimal dose and the combination of FLX plus E2 increased cell proliferation, the number of DCX-labeled immature neurons and the complexity of their dendritic tree, suggesting that these events may be responsible for their antidepressant-like effectes_ES
dc.subject.koFluoxetinees_ES
dc.subject.koEstradioles_ES
dc.subject.koHippocampuses_ES
dc.subject.koOvariectomyes_ES
dc.subject.koForced swimmingtestes_ES
dc.subject.koAdult hippocampal neurogenesises_ES
dc.subject.koDoublecortines_ES


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